Dear Welcome to HCM We understand your concerns I went through your details. I suggest you not to worry much. I am really sorry for your uncle. He is begging to get new treatment mainly because he understood that he is nearing his last days. I don t think you have any options. Keeping him motivated also could be futile. You can convince your doctor to tell your uncle that he has some more days left, could make him a bit positive. If you require more of my help in this aspect, Please post a direct question to me in this XXXXXXX Make sure that you include every minute details possible. I shall prescribe the needed psychotherapy techniques. Hope this answers your query. Available for further clarifications. Good luck.