Lupus diagnosis is considered a little tricky since it can affect many parts of the body by acting like many different kind of the disease. To get a lupus diagnosis, you must show symptoms of lupus in more than one part of your body.On the other hand, lupus is an autoimmune disease, meaning that is caused by an abnormal immune response that turns against the normal cells in your body characterized by the presence of antibodies. This is why the American College of Rheumatology has proposed 11 criteria for lupus diagnosis. If you meet at least 4 (four) of these criteria, a diagnosis of lupus may be made: 1- Rash on the nose and cheeks, called a butterfly rash 2- Raised red patches on the skin, called a discoid rash 3- Sensitivity to sunlight 4- Mouth or nose ulcers 5- Arthritis 6- Heart or lung changes 7- Nervous system changes 8- Kidney changes 9- Blood changes (anemia, leucopenia,ect) 10- Antibodies to ds DNA 11- ANA present in the blood Even though, there is not a single test to confirm or rule out lupus. In your case, since you report only a butterfly rash disappeared after using some creams the diagnosis of lupus seems to be less probable. Although, I would suggest you to consider an lab evaluation: a complete blood count (hemogram), antibodies to double stranded DNA and anti-Sm antibodies. If all these result are in the reference range than you can rule out lupus. For further questions , feel free to contact me again.