Hi, I read your query and can understand your concern. Your problems of depression, anxiety and early ejaculation (premature ejaculation) can be taken care of with proper evaluation and management. I would suggest you seek psychiatric consultation for the same. You can be treated with medications in addition to behavior therapy methods. Selective serotonin reuptake inhibitors like paroxetine are effective as well as safe for anxiety and depression. In addition, it also acts to increase the ejaculation time. Hence, a single medication can be used for all your symptoms. In addition, behavior therapy sessions focusing on relaxation exercises, sex education and learning methods like squeeze and distraction will help in maintaining a relaxed state and increasing ejaculation time. For better chances of success, your wife should attend the sessions with you. Hope this information was helpful. Best wishes.