My husband has Primary AL Amyloid; he had a stem cell transplant in March 2011 but the disease returned in November 2011. He has began treatments with valcade; mephalan & steroids every week since end of December. He recently had to have a transfusion because of low platelets & his breathing is really bad because of added problem of COPD. It doesn t seem like chemo treatments are working & they may have to lower dosage? Will this increase risk of disease getting worse? Does Amyloid hurt when things are working to keep it at bay?