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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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INR Is Low But Not Changed Eating And Drinking Habits. Why There Is Change In Taking Dose Of Warfarin?

my husband has been on warfarin for over a year. everything was pretty stable. Now his INR has been below 2 even though he has not changed his eating or drinking at all. He was taking 3mg of warfarin 5 days a week, 2 mg two days a week. Now he is on 4mg every day. Why is this changing?
Mon, 20 Jan 2014
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Internal Medicine Specialist,  's  Response
Hi, metabolism of warfarin is dependent on how liver is dealing with it. The enzymes required for its metabolism are frequently interfered by many processes that are not yet totally unveiled.It might be a drug, spinach or a small clove or onion piece. so, even when nothing apparently changes, INR can yet change. the point is you need to adjust the dose accordingly to keep the target INR. hope this helped.
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INR Is Low But Not Changed Eating And Drinking Habits. Why There Is Change In Taking Dose Of Warfarin?

Hi, metabolism of warfarin is dependent on how liver is dealing with it. The enzymes required for its metabolism are frequently interfered by many processes that are not yet totally unveiled.It might be a drug, spinach or a small clove or onion piece. so, even when nothing apparently changes, INR can yet change. the point is you need to adjust the dose accordingly to keep the target INR. hope this helped.