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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Is Digoxin And Levothyroxine Contraindicated When Taken Together?

My grandmothers Digoxin level is 2.1. She is not symptomatic at the moment. Her TSH is 8.0 and she is on levothyroxine. I can expect for her PCP to lower her Digoxin dose and increase her Levothyroxine, correct? Do these drugs have anything to do with one another?
Tue, 9 Jun 2015
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Cardiologist,  's  Response
Hello!

Thank you for asking on HCM!

Regarding your concern

It is observed that Levothyroxine decreases effects of Digoxine by unknown mechanism.

So, a close monitoring is necessary in such case.

If an increase in Levothyroxine dose is necessary, then Digoxin effects may be lowered even more; so a dose adjustment would be necessary.

As Digoxin level is 2.1 nmol/L, then probably a renal dysfunction should be sought and a dose reduction may be the rationale (as Digoxin is primarily eleminated through kidneys).

Hope to have been helpful! Greetings! Dr. Iliri
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Is Digoxin And Levothyroxine Contraindicated When Taken Together?

Hello! Thank you for asking on HCM! Regarding your concern It is observed that Levothyroxine decreases effects of Digoxine by unknown mechanism. So, a close monitoring is necessary in such case. If an increase in Levothyroxine dose is necessary, then Digoxin effects may be lowered even more; so a dose adjustment would be necessary. As Digoxin level is 2.1 nmol/L, then probably a renal dysfunction should be sought and a dose reduction may be the rationale (as Digoxin is primarily eleminated through kidneys). Hope to have been helpful! Greetings! Dr. Iliri