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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Is Bone Cancer Hereditary?

I am 22 years of age and my tail bone has been hurting and I have not fallen. My dad has bone cancer in his tail bone and it bothers me that it is heratitary . Also i have been peeing blood and even though I sweat alot at work I have lost 20 or so pounds in the last 3 to 4 weeks. What does this mean.
Mon, 23 Mar 2015
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Radiologist 's  Response
Hi,
Thanks for writing in.

Medical study shows that primary bone cancer is not definitively caused by a defective gene that can be transmitted in families but close watch on certain conditions is required. But people who have particular genetic syndromes have a higher risk of some types of bone cancer than other people.

There are conditions like Li-Fraumeni syndrome, Rothmund-Thomson syndrome and Retinoblastoma that can have increased incidence of osteosarcoma.

Multiple exostoses is a benign condition can be found in families and appears as multiple bone swellings. People with this condition can develop chondrosarcoma.

Chordomas seem to run in some families. The genes responsible have not yet been found, but familial chordoma has been linked to changes on chromosome 7.

Therefore it will be good if you can have a discussion with your doctor concerning the tumor your father has, though it is unlikely that you have a similar one.

Please consult a doctor for your blood in urine, weight loss and pain in tail bone area. That might happen due to anxiety or due to any condition. Please do not worry.
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Is Bone Cancer Hereditary?

Hi, Thanks for writing in. Medical study shows that primary bone cancer is not definitively caused by a defective gene that can be transmitted in families but close watch on certain conditions is required. But people who have particular genetic syndromes have a higher risk of some types of bone cancer than other people. There are conditions like Li-Fraumeni syndrome, Rothmund-Thomson syndrome and Retinoblastoma that can have increased incidence of osteosarcoma. Multiple exostoses is a benign condition can be found in families and appears as multiple bone swellings. People with this condition can develop chondrosarcoma. Chordomas seem to run in some families. The genes responsible have not yet been found, but familial chordoma has been linked to changes on chromosome 7. Therefore it will be good if you can have a discussion with your doctor concerning the tumor your father has, though it is unlikely that you have a similar one. Please consult a doctor for your blood in urine, weight loss and pain in tail bone area. That might happen due to anxiety or due to any condition. Please do not worry.