Thanks for your question on Health Care Magic.
I can understand your son's situation and problem.
I don't find any relevant connection between
chest tightness and brain pathology.
By his history and description, possibility of GERD (
gastroesophageal reflux disease) is more.
It is due to laxity of gastroesophageal sphincter. Because of this the acid of the stomach tends to come up in the esophagus and cause the symptoms of Central burning
chest pain, burping, chest tightness, pressure etc.
Better to rule out cardiac diseases first. So no harm in doing
Angiography.
But before MRI brain, discuss with doctors about possibility of GERD.
He may improve with
proton pump inhibitors and prokinetic drugs. Ask him to avoid stress and tension. Avoid hot and spicy food.
Don't worry, he will be alright.
Hope I have solved your query. Wishing good health to your son. Thanks.