Hi, thanks for posting your concern in the HCM. My opinion is using cyproheptadine along with dimenhydrinate would increase antimuscarinic side effects such as blurred vision, dry mouth, heat intolerance, flushing, decreased sweating, difficulty urinating, abdominal cramping, constipation, and may also cause drowsiness, rapid heart beats, confusion, and memory problems. Imitrex and Ibuprofen combination may be taken for acute attack. But, Periactin and Dramamine would produce adverse side effects and hence consumption of both is not advisable. Please also avoid alcohol and tobacco also with those medications. Hope you are satisfied with my answer. If you have any further query related to this, please write back. In case you have any new query in future, you can directly ask me questions @ http://www.HealthcareMagic.com/doctors/dr-kaushik-sarkar/68460. I will try my level best to help you. Regards, Dr. Kaushik