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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Is It Safe To Change To Letrozole From Tamoxifen With High Blood Pressure?

I have stage 1 estrogen and progesterone receptive breast cancer...have had a mastectomy...no cancer in lymph nodes....I have been taking tamoxifen for 2.5 years and my doctor just changed me to letrozole....I am very concerned about the side effects...especially weight gain and depression....I have osteopenia and high blood pressure and I am not sure this is a good change What do you think?
Thu, 20 Feb 2014
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Oncologist 's  Response
Hi
Thanks for your query.
In postmenopausal patients, incorporating letrozole gives some extra benefit. Weight gain and depression are not the major concerns but osteopenia is. So you should take calcium, vitamin D, bisphosphonates regularly and monitor bone density while on letrozole.
Hope this helps,
Regards
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Is It Safe To Change To Letrozole From Tamoxifen With High Blood Pressure?

Hi Thanks for your query. In postmenopausal patients, incorporating letrozole gives some extra benefit. Weight gain and depression are not the major concerns but osteopenia is. So you should take calcium, vitamin D, bisphosphonates regularly and monitor bone density while on letrozole. Hope this helps, Regards