Hi, Doxinate contains doxylamine and pyridoxine. It is the first choice of doctors for conditions of nausea and vomiting during the pregnancy ranging from morning sickness to hyperemesis gravidarum. This drug is effective for most of the times for the indications given. However, once a while, if Doxinate is not effective, as an alternative, Ondem is also a relatively safe drug to be used during pregnancy including first trimester of pregnancy. However, the drug should be used under guidance of your doctor, in doses and for duration as advised by your doctor. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Satnarain Bansal, General & Family Physician