Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice. Endogest is the brand name of a hormonal medicine called progesterone. This product is indicated in women trying to conceive if there is proven, documented deficiency of the progesterone hormone (during luteal phase). Once conception has taken place, progesterone hormone is indicated only in pregnancies due to assisted reproductive techniques such as IVF, PCOS etc. or in cases of habitual abortion (repeated miscarriages). Misuse and overuse of progesterone can lead to a number of side effects including fetal death and spontaneous abortion (more so in the first three months of gestation), masculanisation of female fetus (such as unwanted hair on face), birth defects in babies such as cleft palate and heart defects. Therefore in the United States, the use of progesterone during known or suspected pregnancy is banned. Unfortunately due to aggressive promotion by drug companies, progesterone products are being used as if they are tonics. In your case many obstetricians will advice endogest, as benefits is more than risks involved in not taking the drug. I think you can go for it, but their is no harm in asking your doctor once again about the necessity of this drug. If he is confident of what he is doing then you can take but only under his supervision. Hope I have answered your query. Let me know if I can assist you further. Regards, Dr. Santosh Kumar A