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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Is It Safe To Take Sertraline Along With Alprazolam And Clonazepam For Panic Disorder?

I take 150mg of sertraline daily in the a.m. .5mg of alprazolam and 1mg of clonazepam (Klonopin?) late afternoon. Is it OK to is those meds? Been taking this regimene for a long time for Panic disorder and is has helped better than I could have dreamed.The bottle of alprazolam says I can take an additional half tab. Feeling very anxious lately. Don t want to overdose.
Wed, 12 Feb 2014
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Psychiatrist 's  Response
Greetings !

Well as such the 3 drug combination that you are taking is safe but i feel that you should have some time gap between klonopin and alprazolam since both of them belong to the same benzodiazepine drug group and may lead to development of cross tolerance for each other thereby making themselves ineffective after a while.

So while sertraline shall be continued as it is you can take klonopin 1 mg in the afternoon and 0.5 mg alprazolam in the night or late evening so as to maintain whole day effect and control over your anxiety and in addition to this if the need arises in case of overwhelming anxiety despite taking these drugs then you may take an extra 1/2 tablet of 0.5 mg alprazolam PRN that is as and when required.

I hope this helps.

Regards
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Is It Safe To Take Sertraline Along With Alprazolam And Clonazepam For Panic Disorder?

Greetings ! Well as such the 3 drug combination that you are taking is safe but i feel that you should have some time gap between klonopin and alprazolam since both of them belong to the same benzodiazepine drug group and may lead to development of cross tolerance for each other thereby making themselves ineffective after a while. So while sertraline shall be continued as it is you can take klonopin 1 mg in the afternoon and 0.5 mg alprazolam in the night or late evening so as to maintain whole day effect and control over your anxiety and in addition to this if the need arises in case of overwhelming anxiety despite taking these drugs then you may take an extra 1/2 tablet of 0.5 mg alprazolam PRN that is as and when required. I hope this helps. Regards