Is it safe to use duphaston for pcos? How effective is it? I took diane 35 for a year but when i withdrew the periods went irregular again, after 4 months gap i would have my periods for 20 days..just started duphatan for 8 dats and have my first cycle now... Your suggestion? Plus my age is 24 unmarried, always trying to control weight which is really tough, also taking glucophage 250 tds, my tsh, fsh, lh levels are normal