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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Is Methotrexate Level In Body High Because Of Not Being Excreted Or Is Lymes Level High?

My husband has RA and is on methotrexate injections along with a lot of other medications. Recently he was prescribed an antibiotic for possible lymes disease which he took the full course of. After his last blood test he was told that he would need long term antibiotics because the lymes level is very high but that antibiotics interact with his methotrexate. Now I am confused, is it his lymes level that is high or is it possible that his methotrexate level is hight because it isnt being excreted through his kidneys or liver?

Mon, 23 Dec 2013
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Diabetologist 's  Response
it depends on what antibiotic is being prescribed

methotrexate is excreted through the kidney
the idea is that most antibiotics are also removed from the kidney
thereby making the kidney an easy target

the best idea to answer your question would be to monitor the sreum methotrexate levels daily for the next three days when he takes the next injection of methotrexate

best of luck
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Is Methotrexate Level In Body High Because Of Not Being Excreted Or Is Lymes Level High?

it depends on what antibiotic is being prescribed methotrexate is excreted through the kidney the idea is that most antibiotics are also removed from the kidney thereby making the kidney an easy target the best idea to answer your question would be to monitor the sreum methotrexate levels daily for the next three days when he takes the next injection of methotrexate best of luck