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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Is Plasma Exchange Treatment Sufficient For CIDP?

Hello , My father is suffering from CIDP for t he Last 8 months and Hospitalized in the month of March ..We have given an IVIG and Plasma Exchange Treatement to him but there is no imrovement .. he is still on Ventillator support . My question : is there any other cure for this disases
Thu, 24 Dec 2020
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Internal Medicine Specialist 's  Response
Hello,

Treatment with glucocorticoids is another option (60–80 mg prednisone PO daily for 1–2 months, followed by a gradual dose reduction of 10 mg per month as tolerated), but long-term adverse effects including bone demineralization, gastrointestinal bleeding, and cushingoid changes are problematic.

Patients of CIDP who fail therapy with IVIg, PE, and glucocorticoids may benefit from treatment with immunosuppressive agents such as azathioprine, methotrexate, cyclosporine, and cyclophosphamide, either alone or as adjunctive therapy.

CIDP associated with anti-CNTN1 and NF155 antibodies is typically refractory to IVIg, but a few studies suggest a response to rituximab, a monoclonal antibody.

Hope I have answered your queries. Let me know if I can assist you further.

Take care

Regards,
Dr. Tushar Kanti Biswas
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Is Plasma Exchange Treatment Sufficient For CIDP?

Hello, Treatment with glucocorticoids is another option (60–80 mg prednisone PO daily for 1–2 months, followed by a gradual dose reduction of 10 mg per month as tolerated), but long-term adverse effects including bone demineralization, gastrointestinal bleeding, and cushingoid changes are problematic. Patients of CIDP who fail therapy with IVIg, PE, and glucocorticoids may benefit from treatment with immunosuppressive agents such as azathioprine, methotrexate, cyclosporine, and cyclophosphamide, either alone or as adjunctive therapy. CIDP associated with anti-CNTN1 and NF155 antibodies is typically refractory to IVIg, but a few studies suggest a response to rituximab, a monoclonal antibody. Hope I have answered your queries. Let me know if I can assist you further. Take care Regards, Dr. Tushar Kanti Biswas