For 17 months, I've had off and on problems with numbness, tingling and pain in the left foot. At first it was also in the calf and so we thought it was a calf strain plus nerve radiculopathy from my low back (I'm permanently disabled post 'failed back surgery syndrome' and nerve troubles). However, after the calf improved (6-7 months), I began to have the same problems in both the left AND right feet and ankles, radiating at times up to the right knee on the tibia and mid-tibia on the left. After seeing a second neurologist in February and getting prescribed Nuerontin and with no clearer diagnosis than it was somehow from the back (and no new testing), I began to question why for the past two weeks, it's not only been worse in the evening, but it can be bothering me a lot in the morning as well. I looked Perindopril (ACE inhibitor) that I'm on for hbp and saw that it's not a 'frequent', but a possible side effect - muscle weakness, tingling, numbness, etc. It made me ask my regular doctor to do a blood test for potassium level and she also wrote for me to have a Doppler test on the calf. However, the symptom that started this morning is what's concerning me. A regularly, pulsating, short 'throb' in the right calf. Feels like a heartbeat/small throb, but strong enough to be quite painful. I'm to have the blood test done tomorrow, but the Doppler not until Tuesday. Meanwhile the leg keeps throbbing and I can't rest. What is it safe to take to help this? I'm already on 1/2 patch of 35 microgram/hour pain med (Buprenorfin) and 1/2 mg Rivotril (Clonazepan) each night (+ 400 mg Neurontin at night) for the back/nerve pain, but that's not cutting the throb in the calf. Ibuprofen OK?