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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Osteomyelitis, Rapid Weight Loss, Loss Of Appetite, Frequent Urination, Itching, Thyroid. Taking Cefazolin And Augmentin. Suggestion?

I am so frustrated. Please help me. I am in my third month of dealing with a staph infection in my shoulder joint and bone that won't go away and that has caused me to be diagnosed with osteomyelitis. I have been hospitalized twice in these three months and had 5 surgeries to clean shoulder. Now on IV cefazolin and oral augmentin. I have other symptoms as well rapid weight loss, extreme itchiness, frequent urge to urinate, difficulty urinating (must push), loss of appetite, dry, brittle hair, recurring infection as stated above, low testosterone, thyroid disease. My Bloodwork shows normal ranges. Once a month my right ovary seems to get inflamed and causes pain and tenderness in that area. I have had 2 surgeries for endometriosis, but that was long ago. Three successful pregnancies, my youngest is almost five. Don't drink or smoke. Not overweight, I use Mirena IUD for birth control. What is wrong with me?
posted on Sun, 21 Jul 2013
Twitter Sun, 21 Jul 2013 Answered on
Twitter Mon, 22 Jul 2013 Last reviewed on
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Orthopaedic Surgeon, Joint Replacement,  's  Response
Hi, thanks for writing to HCM.

An aggressive method of treament or approach is necessary for Acute osteomyelitis so as to prevent it from not becoming CHRONIC OSTEOMYELITIS.

The mainstay of treatment is by INTRAVENOUS ANTIBIOTICS.
Antibiotic treatment is usually continued for 6 weeks for osteomyelitis. The choice of the antibiotic depends on the sensitivity of the organism to that particular antibiotic.

MRSA (Methicillin resistant staph aureus) is the most common resistant bacteria encountered in orthopedic practice now a days. A 6-week course of vancomycin (1 g IV every 12 hours) is the current standard treatment for MRSA. However, this drug has relatively poor bone penetration, and it requires close monitoring because it can cause nephrotoxicity and ototoxicity.

CLINDAMYCIN has got excellent bone penetration potential and is also active against staph.aureus. So this is preferred but it rarely causes a potentially lethal complication - PSEUDO MEMBRANOUS COLITIS.

Newer antibiotics like LINEZOLID which are active against MRSA are currently available and can be taken ORALLY.

Erythrocyte sedimentation rates (ESRs) and C-reactive protein (CRP) levels should be serially checked weekly or semiweekly to monitor the success of treatment

Hope this information is helpful. Good day



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Osteomyelitis, Rapid Weight Loss, Loss Of Appetite, Frequent Urination, Itching, Thyroid. Taking Cefazolin And Augmentin. Suggestion?

Hi, thanks for writing to HCM. An aggressive method of treament or approach is necessary for Acute osteomyelitis so as to prevent it from not becoming CHRONIC OSTEOMYELITIS. The mainstay of treatment is by INTRAVENOUS ANTIBIOTICS. Antibiotic treatment is usually continued for 6 weeks for osteomyelitis. The choice of the antibiotic depends on the sensitivity of the organism to that particular antibiotic. MRSA (Methicillin resistant staph aureus) is the most common resistant bacteria encountered in orthopedic practice now a days. A 6-week course of vancomycin (1 g IV every 12 hours) is the current standard treatment for MRSA. However, this drug has relatively poor bone penetration, and it requires close monitoring because it can cause nephrotoxicity and ototoxicity. CLINDAMYCIN has got excellent bone penetration potential and is also active against staph.aureus. So this is preferred but it rarely causes a potentially lethal complication - PSEUDO MEMBRANOUS COLITIS. Newer antibiotics like LINEZOLID which are active against MRSA are currently available and can be taken ORALLY. Erythrocyte sedimentation rates (ESRs) and C-reactive protein (CRP) levels should be serially checked weekly or semiweekly to monitor the success of treatment Hope this information is helpful. Good day