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Positive Osmotic Fragility Test, Beta Thalaassemia Trait With Or Without Alpha Thalassemia 1. Explain

Hi, I am 34 y. Ferritin 582.4, flag High (ref range 23.9-336.2); iron (serum) 122, flag Normal ( ref 45-182); TIBC 331, flag normal (ref. 228-428)
Hemoglobin type A2A
Hb A 93.8 percent
Hb A 2 : 5.3 percent , flag High (2.0-3.5)
Hb E : 0 percent
Hb H : 0.9 percent
Hemoglobin (Hb) 12.9, Flag Low ( ref. 14.00-18.00)
Hematocrit ( Hct.) 41.6, flag Normal ( 40.00-54.00)
MCV: 64.7 flag low,(80.0-96.0)
Osmotic Fragility Test: Positive
Interpretation: Beta thalassamia trait with or without alpha thalassemia 1.
Please kindly what is my health condition for thalassemia and treatment should be taken.
Tue, 5 Nov 2013
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Pathologist and Microbiologist,  's  Response
Hello and welcome to HCM,
Thalassemia (thal) is a blood related disorder.
It is of two types- thal beta and thal alpha.
Depending on the severity of the disease, it is trait, minor or major.
Heamoglobin molecule is made up of two pairs protein chain called - alpha and beta.
A decrease or absence of any one of these two pairs causes alpha or beta chains.
So, in your case there is involvement of beta chain.
If the beta chain is completely absent, it is called thal beta major.
If the chain is present but in lower quantity it is called thal trait or thal minor.
The trait is first detected at the age of 34 years in your case.
It was not symptomatic during your childhood and adolescence so there is nothing to worry.
Hemoglobin level is also marginally low so nothing practically needs to be done.

Thanks and take care
Dr Shailja P Wahal
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Positive Osmotic Fragility Test, Beta Thalaassemia Trait With Or Without Alpha Thalassemia 1. Explain

Hello and welcome to HCM, Thalassemia (thal) is a blood related disorder. It is of two types- thal beta and thal alpha. Depending on the severity of the disease, it is trait, minor or major. Heamoglobin molecule is made up of two pairs protein chain called - alpha and beta. A decrease or absence of any one of these two pairs causes alpha or beta chains. So, in your case there is involvement of beta chain. If the beta chain is completely absent, it is called thal beta major. If the chain is present but in lower quantity it is called thal trait or thal minor. The trait is first detected at the age of 34 years in your case. It was not symptomatic during your childhood and adolescence so there is nothing to worry. Hemoglobin level is also marginally low so nothing practically needs to be done. Thanks and take care Dr Shailja P Wahal