Hi, Thanks for using the HCM. I am happy to address your questions, antidepressant medicines act on nerve cells in the brain. In the brain there are numerous different chemical compounds called neurotransmitters. These act as chemical messengers between the nerve cells. Serotonin is one such neurotransmitter and has various functions. Selective Serotonin Reuptake Inhibitors (SSRIs) like Cipramil (citalopram) work by preventing serotonin from being reabsorbed back into the nerve cells in the brain. This helps prolong the mood lightening effect of any released serotonin, in this way, helps relieve depression, anxiety and fear. Cymbalta is in a class of medications called selective SNRIs (serotonin and norepinephrine reuptake inhibitors) and is also indicated for the treatment of major depressive disorder and anxiety disorders. It is believed to be related to an increase in the activity of serotonin and norepinephrine, which are two naturally occurring substances in the brain and spinal cord. The most common side effects identified in patients taking Cymbalta or Cipramil include nausea, dry mouth, sleepiness, fatigue, constipation, dizziness, decreased appetite, increased sweating. The dose strength may differ due to a different chemical composition. Will recommend you to kindly consult your physician before switching medications. Hope I have answered your query. If you have any further questions I will be happy to help. Thanks