Hello and welcome to HCM, Thank you for your query. At first, all your BP readings are quite high and require proper management. If these particular medications are not bringing them, it is best to substitute them. Your first few adverse effects match adverse effects that could be caused by the drug metaprolol, i.e. hair loss, exhaustion and cough. Bactiver plus is the antibiotic chosen by your doctor for management of your UTI, this cannot cause the side-effects mentioned by you, and has been chosen depending on the sensitivity given in your urine culture report. As you are now reporting insomnia, which is not a common side-effect but could be the result of other side-effects like mood changes, depression or even bradycardia. In my opinion substituting metaprolol would be the best thing to do right now. There are so many BP medications in the market, only so we can treat the different kind of patients presenting to us. If you are worried about monitoring, you could request your doctor for a 24 hour holster device monitoring, which would record your BP every 5-10 mins, and see how it fluctuates through the day. Please discuss early management of your blood pressure and substitution of your BP medications, as so many adverse-effects are uncommon. I hope I have succeeded in answering your questions, you could write back to us anytime for further clarifications. Best wishes.