I will be starting methotrexate for rheumatoid & osteo arthritis , beginning tomorrow. Is it safe to also take Vicodin at times when I am in pain and want to be able to function comfortably when I m not at home. I typically take up to (3) vicoden per WEEK -- if I have pain but have commitments that require me to be away from home (helping parents etc). I don t know if the methotrexate will provide the relief I need at those times in order to be able to function. I was also told by my new rheumatologist that it could take up to (6) weeks for full effect of Methotrexate to kick in. Is it safe to take the Vicodin as needed. My Rx (from my Internist) reads: HYDROCODONE-APAP 5-500. I forgot to ask my Rheumatologist about this. Thanks for your help!