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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Previously Been On Actonel For Some Years. Scan Shows Osteopenia Has Become Early Osteoporosis. Advised Reclast, Prolia. Safe? Side Effects?

At 60, have previously been on Actonel for 7 years (prior to menopause) and now bone density scan shows Osteopenia has become early osteoporosis in my spine. Now my doctor recommends Reclast as a first choice, Prolia as a second and Evista as a third choice. The side affects really frighten me. How safe is Reclast or Prolia? Evista seems the least of all the evils
Thu, 11 Jul 2013
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General & Family Physician 's  Response
Hello.I agree with your doctor. High to low effectiveness are: Zoledronate, Denosumab and Raloxifene.
Zoledronate is used for many years, with little adverse effects .
Is important to know that is contraindicated in people with kidney failure.
Denosumab is effective but there is less experience using although it is a valid option.It is contraindicated in people with low calcium in blood.
Raloxifene is another valid option but with lower effectiveness.
I wish you good health.
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Orthopaedic Surgeon, Joint Replacement Dr. K. Naga Ravi Prasad's  Response
Hi, thanks for writing to HCM.
In Allopathic system of medicine, every drug produces certain degree of side effects when used for a prolonged period of time.
Prolia (Denosumab) and Reclast ( Zolendronic acid) are used to treat osteoporosis in post menopausal women who have high risk of bone fracture. Both these may produce serious side effects and mainly damage to the kidneys.
Evista (Raloxifene) is the best pick among the three and has few advantages over the other two drugs. Evista falls under the category - SERM ( Selective estrogen receptor modulators) and produces natural "hormone like effects" apart from it usefulness in preventing post menopausal osteoporosis.

Hope this information is helpful to you. Good day

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Previously Been On Actonel For Some Years. Scan Shows Osteopenia Has Become Early Osteoporosis. Advised Reclast, Prolia. Safe? Side Effects?

Hello.I agree with your doctor. High to low effectiveness are: Zoledronate, Denosumab and Raloxifene. Zoledronate is used for many years, with little adverse effects . Is important to know that is contraindicated in people with kidney failure. Denosumab is effective but there is less experience using although it is a valid option.It is contraindicated in people with low calcium in blood. Raloxifene is another valid option but with lower effectiveness. I wish you good health. (In case the answer would have been useful please indicate this)