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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Should I Take Progesterone For Uterine Tissue Proliferation?

I m 67 years old and I ve been on Estring for 2+ years for vaginal dryness and itching with no apparent issues. My doctor recently suggested that I also start a low dose progesterone to avoid uterine tissue proliferation. I have an intact uterus and have been menses free for 15 years. Is this a new recommendation...adding progesterone? Can you provide any study links?
Thu, 5 Nov 2015
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General & Family Physician,  's  Response
Hi and thanks for asking us on HCM.

Your doctor is quite correct to ask you to go on progesterone as it does protect against uterine proliferation. You need to go on this long-term to reap full benefits.

We are not allowed to paste links or the answer will be rejected:
Kindly google this study and read the abstract on pubmed:
micronized progesterone regulation of the endometrial glandular cycling pool

Another related study (fairly recent) would be the following. Again, kindly google:
Loss of progesterone receptor links to high proliferation and increases from primary to metastatic endometrial carcinoma lesions


Thank you
Dr Shabnam
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Should I Take Progesterone For Uterine Tissue Proliferation?

Hi and thanks for asking us on HCM. Your doctor is quite correct to ask you to go on progesterone as it does protect against uterine proliferation. You need to go on this long-term to reap full benefits. We are not allowed to paste links or the answer will be rejected: Kindly google this study and read the abstract on pubmed: micronized progesterone regulation of the endometrial glandular cycling pool Another related study (fairly recent) would be the following. Again, kindly google: Loss of progesterone receptor links to high proliferation and increases from primary to metastatic endometrial carcinoma lesions Thank you Dr Shabnam