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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Should Intermitted Triple Hormonal Therapy Be Given For Person With Prostrate Cancer?

Hi, This query is for my dad who is 70 yrs old and was diagnosed first with Metastatic Prostate cancer in 2006. He had orichetocomy same year and has been on hormone therapy (androgen deprivation via bicalutimide pill) since then. His PSA levels were very low (below 1) in the first 2 years after surgery. Now it is 5. I read about intermitted triple hormonal therapy and use of 5-ARI inhibitors. Should we be given any of these ? His Oncologist though supposedly a reputed one does not do a good job of explaining why current treatment regime is OK. His bone scan from 2 months ago showed the images looked same as when we was first disagnosed. Look forward to valuable advice

Mon, 21 Sep 2015
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Oncologist,  's  Response
hello dear. I appreciate your concern. In my clinical practice we do not advise triple hormonal blockade in a case of metastatic disease as it offers little benefit. More over more effective therapies are available now. As far as a patient of prostate cancer is asymptomatic and doing well and does not show any disease progressions on scans, we do not change the treatment irrespective of the PSA levels. In my opinion your father is doing fine so no need to change the therapy and hence your doc is doing good. if he progresses to symptoms or show some new abnormalities on scan then we can go with chemotherapy or some other androgen blockade therapy. Yor\ur father has still very good amount of life to live so do not worry. Take care, Hope this solves your query.
regards
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Should Intermitted Triple Hormonal Therapy Be Given For Person With Prostrate Cancer?

hello dear. I appreciate your concern. In my clinical practice we do not advise triple hormonal blockade in a case of metastatic disease as it offers little benefit. More over more effective therapies are available now. As far as a patient of prostate cancer is asymptomatic and doing well and does not show any disease progressions on scans, we do not change the treatment irrespective of the PSA levels. In my opinion your father is doing fine so no need to change the therapy and hence your doc is doing good. if he progresses to symptoms or show some new abnormalities on scan then we can go with chemotherapy or some other androgen blockade therapy. Yor\ur father has still very good amount of life to live so do not worry. Take care, Hope this solves your query. regards