I have been on zoloft and pristiq for nearly 3 months now. My deep depression which pretty much keeps me house bound, and I still have severe depressing days. My serious depression has been going on for some time now, well over 2years. Although I may see a small difference some days my depression is still very debilitating. No interest in things I used to enjoy, don t want to go anywhere or socialize with others. I have become very close to a recluse. If I keep taking both these meds will I ever see a big difference and actually feel happy again, I m a 64 year old female.