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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Side Effects Of Taking Isoniazid On Liver? Alternative?

I have been taking Isoniazid 300mg 1x day (this is the first month of of a nine month treatment) and am concerned about the med s effect on my liver ( toxicity ). 1)Is there anything that can reduce the toxic side effect? 2) Would fiber psylium supplement be beneficial or not a good idea to help rid the body of waste (acetylisoniazid)?
Wed, 1 Aug 2012
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Endocrinologist,  's  Response
The question is why are you taking Isoniazid ? Is it for prophylaxis or is it part of tuberculosis regimen ? Yes Isoniazid has liver toxicity but not in all patients .. Only some patients develop raised liver enzymes because of isoniazid. Do have an underlying liver disease ? If not there is nothing to worry. Go for a baselne Liver function test and repeat it after three months , if the ALT and AST has not increased by > 3 times the upper limit of normal then there is nothing to worry. You dont need to take any other medications to prevent liver toxicity.
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Side Effects Of Taking Isoniazid On Liver? Alternative?

The question is why are you taking Isoniazid ? Is it for prophylaxis or is it part of tuberculosis regimen ? Yes Isoniazid has liver toxicity but not in all patients .. Only some patients develop raised liver enzymes because of isoniazid. Do have an underlying liver disease ? If not there is nothing to worry. Go for a baselne Liver function test and repeat it after three months , if the ALT and AST has not increased by 3 times the upper limit of normal then there is nothing to worry. You dont need to take any other medications to prevent liver toxicity.