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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Suggest Medication For Depression While On NSAIDs

I am currently taking NSAID's for chronic back and neck pain with the occasional vicoden when it gets very intense. What antidepressant would be best for my depression? I've read SNRI's are better as SSRI's effects are diminished with NSAID and pain meds.
Tue, 23 May 2017
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Psychiatrist,  's  Response
Hi Sir/Madam
Welcome to Health Care Magic

I can certainly understand your concern about the combined effect of NSAIDs and SSRIs , as you said it may reduce the effectiveness because of some cytokine receptor occupation by both the drugs, so there will be less receptors available for SSRIs

But I can suggest you can start on desvenlafaxine which is an SNRI , as due to the combined effect of norepinephrine and serotonin, you can get good results...But it is advisable not to stop this medication
Before 6-9 months , even if you feel better as you may get relapse of the symptoms...If you stop the course incompletely, hope this information would help you

Please post your further questions if any, I will be always available to answer them
Thank you



Post your further questions if any, I will available to take up your follow up questions

Thank you
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Suggest Medication For Depression While On NSAIDs

Hi Sir/Madam Welcome to Health Care Magic I can certainly understand your concern about the combined effect of NSAIDs and SSRIs , as you said it may reduce the effectiveness because of some cytokine receptor occupation by both the drugs, so there will be less receptors available for SSRIs But I can suggest you can start on desvenlafaxine which is an SNRI , as due to the combined effect of norepinephrine and serotonin, you can get good results...But it is advisable not to stop this medication Before 6-9 months , even if you feel better as you may get relapse of the symptoms...If you stop the course incompletely, hope this information would help you Please post your further questions if any, I will be always available to answer them Thank you Post your further questions if any, I will available to take up your follow up questions Thank you