I have had problems with depression meds NOT working. After being prescribed many different drugs...... Cymbalta, Effexor, Wellbutrin, Parnate,.........my doctor now has Rx d EmSam....the patch. Last Monday was the beginning, making today one week s use. I do not think it is helping to improve my mental energy and depression. I have lost my husband.....died last July; My mother passed away Feb 21 of this year. I am a Christian, and I just cannot snap out of feeling horrible!