I have had severe allergic reactions several times that have sent me to the hospital. These have happened over the course of 10 years. They happen only at night after I have been asleep for at least an hour but sometimes after I have slept a few hours. They are becoming more frequent. Any weird allergies that only make you sick at night? It starts with an upset stomach and then moves to either my insides becoming hot or my hands and feet itching. Sometimes I can take a benedryl and be fine but sometimes I go into anaphalactic reactions. I had an epipen for six years and never had to use it and know have had to use it twice in 3 weeks.