I read your question and i am able to understand your concern. To help you understand better, I would like to share some general information about diabetes pathology. There are two main features involved. 1.insulin resistance 2. insulin production defect from beta cells of pancreas. During initial stages of diabetes the insulin supply and demand can be maintained by reducing insulin resistance. This is achieved by drugs like metformin and physical activity. But in due course of time beta cell capacity to produce insulin will decrease and blood sugars cannot be maintained. Hence we depend on second line of medication to increase the production of insulin from beta cells by using drugs like glucophage and glimipride. The medication what you are using is a very good medication it helps in controlling diabetes and reduce insulin resistance. i suggest you to go for daily walking for 45mins as exercise is very important in diabetes. following a strict diet plan is also very important in diabetes kindly take suggestion from your treating doctor on discontinuing of losamerm because a part of blood pressure control it is having many other benefits like prevention of diabetes nephropathy. regards Dr vamsi