Hi. Thanks for posting your concern at HCM You are on the right kind of medication for acne control. Deriva-BPO and Acnovate gel contain Adapalene which is a wonderful antiacne drug because of its comedolytic action and anti-inflammatory action. I would suggest that you continue with it once daily at night. Your dermatologist might need to add an oral antibiotic like doxycycline or azithromycin if need be. I must mention about Oral Retinoids: For severe acne OR for acne unresponsive to traditional anti-acne medications, Isotretinoin can be started. It the only drug which offers any chance of long term cure and after a full course of isotretinoin significant number of people never have a recurrence of there acne. It should be taken under the supervision of a dermatologist because of certain lab tests which are to be done before and during treatment with isotretinoin. I would advice you to see your dermatologist and have a discussion with him/her keeping all these points in mind. regards