Hi. Thanks for your query. Read the history about your husband and understood the problems. Liver transplant patients need a careful treatment. Shortness of the breath could have been investigated for possible Pneumonia, asthma, allergy or so, which you have not mentioned anything about. I wonder how the pain medicines could have helped. If the colon is inflamed, he needs more careful investigations and treatment as all the things absorbed by the large bowel - the colon will be filtered by the liver and may cause damage to the transplanted liver. I would advise you the following: Take your husband to the Liver Transplant Center. Get colonoscopy and investigations of the blood, stool and urine- the liver, kidney function. Further treatment will be as per the findings and will be specific for the cause .