Hi, You said you suffer from acne. Acne may be in different forms like white comedones,black comedones,inflammatory papules,nodules,cysts..etc. and remember acne is a relapsing disease and might be exacerbated by factors like stress,anxiety,sleeplessness,oily food,dandruff,drugs like pills,steroid... Your query is regarding the use of isotretinoin. You developed chelitis due to isotretinoin. I can understand your worry. But, in high dose isotretinoin does cause side effect like cheilitis. So, in my patients I usually recommend low dose of isotretinoin. For control of acne I would like to give few suggestions as below.. - avoid all factors which might exacerbate,as suggested above - take antibiotics like azithromycine or minocycline in proper dose - tab isotretinoin 5 mg low dose might cause improvement - apply clindamycine gel on the lesions in morning - adapalene gel may be applied at night - cleanse the face with cetaphil lotion Avoid acne related anxiety and tension. Be patient to get early result. I think,this would be helpful to you. Still consult dermatologist. Thanks. Dr. Ilyas Patel MD