Good Afternoon, I m sorry to hear of you and your sister s difficulties. This must be a very hard experience to have and go through. Unfortunately brain damage is very difficult if not often times impossible to reverse. Nonetheless there are options to seek improvement. Physical therapy, occupational therapy, speech therapy and comprehensive brain injury rehabilitation services can be utilized to help increase the activity and function of your sister s brain; and as a result, this therapy may recruit more areas of the brain which are active to take over the portions of the brain which have been damaged beyond repair. In some cases with this therapy, some portions of the brain damaged, but still with adequate blood flow and or some semblance of remaining function can be brought back to higher if not near-normal to normal function. Nonetheless, there are no medications or surgeries which can reverse portions of the brain with definitive damage. If your sister experiences symptoms that result from this brain damage (pain, loss of function, spasms, seizures, neurological changes), there are of course medications and targeted therapies which can be used to help; but the damage itself, as stated above, is more difficult to treat, and I recommend seeking the above listed therapies. I wish you and your sister the warmest and happiest of holidays; and trust even with such difficulties, that there will be happiness and things that can give you comfort and enjoyment. Family, friends, conversation and of course therapy will all in my professional experience lead you in the right direction. I hope my experiences and advise matches well to your personal case; and will lead you in the correct direction. If not, I, and other physicians are always available for further discussion.