Hi. Thanks for your query. Noted the history extreme heartburn and stomach acid, feel hungry and full, taken Pepcid AC, awake in night, wants to know whether to use Omeprazole and Ranitidine that you used in past, travelling on Monday... I would advise you the following in such a situation: Take Omeprazole Take antacid 3 hourly, particularly when on empty stomach. Also needed is a motility regulator like Domperidone. This am y relieve your problems and pains to give you comfortable good night s sleep. If not you can consult your Doctor to get a proper prescription of the medicines as mentioned above, and the medication for your stress and/or anxiety to get a proper sleep which in itself helps in symptomatic relief also. If there is no relief and since your problem looks to be recurrent , it is better to get an upper GI Endoscopy and ultrasound too and further management. Take a soft bland diet. Avoid smoking and oily and spicy foods. No alcohol or aerated beverages at all. Identify the factors that instigate or enhance your symptoms and stop/avoid them altogether.