Hello I have gone through your question. I can understand your concern. Depression ,weight gain and cravings can be symptoms and signs of hypothyroidism and in your case this means that your thyroid condition is not yet stabilised. In these circumtances it is recommended to do a TSH test and to increase the dosis of Synthroid (levothyroxine0 accordingly. I want to undeline that all these problems will gradually disappear when your thyroid test will return to the normal range.Than a healthy lifestyle,an healthy hypocaloric plan meal and regular exercise will help you to loose weight. The OxyElite Pro is a dietary supplement that suppress the appetite and in this way speeds up the fat-burning process.Lots of people use this sulplemment and they say that it very effective. But,i want to say you to be careful because there are not reasonable data of the safety of some of his ingredients and FDA has started an investigation about this product because it is suspected a possible link between OxyElite Pro products and cases of liver failure and non-viral hepatitis. About your question ,i can say that Synthroid works best if you take it on an empty stomach, before breakfast and if you avoid taking other drugs within 4 hours before or 4 hours after you take Synthroid. So,If you decide to continue oxyELITE Pro supplement,there is no problem but you must take it at least 4 hours before or after Synthroid(levothyroxine). Anyway,I suggest to consult immediately your treating doctor if you have uncommon symptoms after taking the fat burning supplements and your synthroid. Hope a have answered to all your questions. If you have other doubts,feel free and ask. Regards.