I have been on 580mgs of morphine!!!! a day for 4 years for back pain. I have been taken off and now suffer from chronic pain Found out pain causes a rise in the D2 enzyme, which causes an increase in brain thyroid conversion and a decrease in D1 enzyme, which is for body thyroid conversion. Because of this my TSH has gone to .045 where dr s (not knowing about D1,D2,D3) think I have hyperthyroidism and want to give me a thyroid lowering drug which, for me, will make things WORST. I cannot find anything on high brain thyroid. Question: 1) what will high brain thyroid do? 2) other then back surgery to lower pain how can I correct this thyroid problem?