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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Suggest Treatment For Low Grade B-cell Non-hodgkin’s Lymphoma

Respected Dr, I am a 46 years old male with HBV+ve with the viral load of 1820 copies/mL. This HBV disease was initially detected long years ago about 15 years back, I started treating it with Tenofovir 300 mg OD for three months when the viral load became below detection limit. I stopped taking this medicine and the viral load has again increased at current level of 1820 copies/ml. I was diagnosed with another chronic illness of Ulcerative Colitis/IBD during 2012 after my colonoscopy and the Biopsies of all parts of my Colon. Doctors treated me with Tab Mesacal 800mg with Deltacortril 5mg (prednisolone) three times a day. This medication produced very minor positive results. After Six month time period Doctors advised me to taper off the Deltacortril 5mg (prednisolone) and finally stop it. The symptoms of the disease remain as it is and blood, Mucus and Puss with stool was the common complication which led to my weight loss from 75 kg to 68 kg and now its decreased to 64 Kgs almost. After passing two years I was very upset with this illness and decided once again to get my Colonoscopy done. Finally My Colonoscopy procedure was done on June 19, 2014 at Shaukat Khanum Memorial Cancer Hospital and research Centre and 4 Biopsies from right and left Colon, terminal ileum and Rectum were taken for Histopathology Report. The report received on July 2, 2014 with the diagnosis /findings of Low grade B-Cell non-Hodgkin’s Lymphoma consistent with MALT-Lymphoma. The report says that all four parts are affected and are ulcerated. The PET Scan report also maintain the fact that hypermetabolic wall thickness is seen in large intestine with entire length of descending colon, Sigmoid colon & rectum. I have consulted many Oncologists here in Lahore for its treatment options. They are of the view that this type of Low Grade Lymphoma is not curable disease but we can put it in remission with multiple Chemo options of CHOP, CVP, R-CVP or FM plan. Due to my HBV+ve disease they have suggested me with CVP option only to keep the treatment safe which does not trigger the Hepatitis B. My Consultant doctors (Medical Oncologist and Clinical Oncologist) at Institute of Nuclear Medicine and Oncology Lahore (INMOL) have started my Chemotherapy first dose on July 21, 2014, with the medical CVP option (Inj Cyclophosphamide 1Gm, Inj Vinracine 2mg and Solu-Medrol injection 500 mg in 4 divided doses 125 mg per day with Inj Granicip, Inj Avil and Inj Dexamethasone 1ml). They have suggested me to revisit after 15 days and may be they will go for second dose after passing 21 days to the first dose (on August 11, 2014) You are requested to support me for better guidance with regards to my disease current situation/stage and best treatment options from various treatment plans of Lymphoma/cancer treatment. Thanks and very kind regards, Naeem Masood Chishti YYYY@YYYY
Fri, 5 Jan 2018
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Oncologist 's  Response
HI

First line treatment for low grade B-cell non-hodgkin’s lymphoma
include a combination of chemotherapy and a type of biological therapy called a monoclonal antibody. The most common combination is called R-CVP. This combines the chemotherapy drugs cyclophosphamide and vincristine, the steroid prednisolone and a monoclonal antibody called rituximab.

If you are not fit enough to have combination chemotherapy, you might have chlorambucil chemotherapy tablets. You can take these at home. You might take them with the steroid prednisolone.

Maintenance treatment
Once you are in remission you might have maintenance treatment for some types of low grade lymphoma. Maintenance treatment might help to delay the lymphoma from coming back.

For follicular lymphoma, you have the biological therapy drug rituximab every 2 months for up to 2 years.

Second line treatment
Some types of low grade lymphoma tend to come back after a period of time. You need more treatment if this happens. The next lot of treatment you have is called second line treatment.

There are lots of options. You might have one of the following:

a combination of 3 or 4 chemotherapy drugs with rituximab
R-CVP again if you were in remission for a long time
a single chemotherapy drug called fludarabine
fludarabine in combination with rituximab, mitoxantrone and the steroid dexamethasone
Your doctor considers a number of things before deciding what is likely to be the best treatment for you. These include:

your previous responses to treatment
how quickly they want the treatment to work
convenience for you
You might have rituximab as a maintenance treatment for up to 2 years if your lymphoma goes back into remission after chemotherapy.

Regards
Dr DE

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Suggest Treatment For Low Grade B-cell Non-hodgkin’s Lymphoma

HI First line treatment for low grade B-cell non-hodgkin’s lymphoma include a combination of chemotherapy and a type of biological therapy called a monoclonal antibody. The most common combination is called R-CVP. This combines the chemotherapy drugs cyclophosphamide and vincristine, the steroid prednisolone and a monoclonal antibody called rituximab. If you are not fit enough to have combination chemotherapy, you might have chlorambucil chemotherapy tablets. You can take these at home. You might take them with the steroid prednisolone. Maintenance treatment Once you are in remission you might have maintenance treatment for some types of low grade lymphoma. Maintenance treatment might help to delay the lymphoma from coming back. For follicular lymphoma, you have the biological therapy drug rituximab every 2 months for up to 2 years. Second line treatment Some types of low grade lymphoma tend to come back after a period of time. You need more treatment if this happens. The next lot of treatment you have is called second line treatment. There are lots of options. You might have one of the following: a combination of 3 or 4 chemotherapy drugs with rituximab R-CVP again if you were in remission for a long time a single chemotherapy drug called fludarabine fludarabine in combination with rituximab, mitoxantrone and the steroid dexamethasone Your doctor considers a number of things before deciding what is likely to be the best treatment for you. These include: your previous responses to treatment how quickly they want the treatment to work convenience for you You might have rituximab as a maintenance treatment for up to 2 years if your lymphoma goes back into remission after chemotherapy. Regards Dr DE