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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Suggest Treatment For Prostate Cancer

Hello, My husband 65 has prostate cancer with mets sinse may of last year. His PSA is very high, but ALK phosphates start coming down. It was 176 in July and now is 145. His cancer is resistant to hormonotherapy and he is doing radiation therapy to his painful hip with metastasis. Please advise if decrease in ALK phosp. is good sign and if he should continue with Lupron shots. Thank you.
Mon, 9 Feb 2015
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Oncologist, Surgical 's  Response
Firstly, you need to be sure whether it is hormone resistant. Better than Lupron shots is to get a bilateral orchidectomy done which is removal of both testis. It is a simple surgery and has a more predictable effect than Lupron. Also, he should be placed on an anti-androgen like bicalutamide after the orchidectomy. Only fall in PSA is a sign that the disease is getting controlled, ALK phos has no value alone.
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Suggest Treatment For Prostate Cancer

Firstly, you need to be sure whether it is hormone resistant. Better than Lupron shots is to get a bilateral orchidectomy done which is removal of both testis. It is a simple surgery and has a more predictable effect than Lupron. Also, he should be placed on an anti-androgen like bicalutamide after the orchidectomy. Only fall in PSA is a sign that the disease is getting controlled, ALK phos has no value alone.