Thank you for the query. I would like to know your age, gender and whether you suffer from any associated comorbidities like Diabetes mellitus. I would also like to know what group of antibiotics were taken by you. As per the history, you are suffering from recurrent Urinary Tract Infection, with raised infection parameters (TLC-24000/mm3 and ESR-40). Recurrent UTI can occur due to a number of different causes in males and females. Uncontrolled Diabetes is an important cause for both genders, hence it is advisable to get your blood sugar screened (fasting and post prandial blood sugar). In elderly male patients prostatomegaly is an important cause, which can lead to recurrent UTI. In elderly female subjects, bladder neck obstruction (mainly age related) can cause raised residual urinary volume, which can again lead to recurrent UTI. A ultrasonography of kidney-ureter-bladder with assessment of residual urinary volume helps in this case. Inadequate antibiotic dosage for inadequate duration is another important cause of recurrent UTI. This can lead to emergence of drug resistant bacterial strains, which become difficult to treat. A urine for routine examination and culture is needed (though in all probabilities your culture may be negative since you have received multiple courses of antibiotics). I would advise you to consult your physician since you need a thorough check up and some specific investigations, as your infection parameters are raised (an intravenous course of high end antibiotics may well be required after assessment). It will be slightly difficult to manage your case at home, since you are not responding to oral antibiotics. Personal hygiene is very important for prevention of UTI (keep your private areas clean and dry) and plenty of oral fluid intake is advisable. Hope this helps you.