Hello, Medication options for severe depression may include antidepressants, such as selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants (TCAs), or monoamine oxidase inhibitors (MAOIs). These medications work by altering the balance of chemicals in the brain that affect mood. In addition to medication, psychotherapy can be helpful for treating severe depression. Cognitive-behavioral therapy (CBT) is a common type of therapy that helps individuals identify and change negative thought patterns and behaviors. Other types of therapy, such as interpersonal therapy (IPT) or psychodynamic therapy, may also be effective. For some people with severe depression, electroconvulsive therapy (ECT) may be recommended. ECT involves passing a small electrical current through the brain to induce a seizure, which can help alleviate symptoms of depression. It is important to work closely with your mental health provider to develop a treatment plan that is tailored to your specific needs and to attend all scheduled appointments to ensure the best possible outcomes. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. H. Kay, General & Family Physician