Dr. I have suffered with migraine for over 30 years and used both tonopan and vasograine, the former provided better relief, but to the cost, tonopan was discontinued and i stayed with vasograine. I usually get an attack twice or trice a week, sometimes a week passed without an attack. Now for the past two weeks, i get an attack daily, especially at around 2:00 am. Please advise what may be happening?