I m a male and will be 61 next week. I m generally very healthy, active and in good physical condition. I ve noticed my right toenail looks swollen & enlarged in comparison to my left with white powder around the nail. I ve a prescription for nystatin foot powder for a couple of years. It was what finally got a nagging case of athlete s foot under control. Nothing else had worked for 15+ years after a product I had previously used was taken off the market because one of the ingredients became FDA banned. The white powder is strange, at first, I thought it was a build up of the foot powder, but I seem to notice it more at certain times, but I haven t been able to link it to environmental or other circumstances.