I ve been on Depo for about 2 years....I am aware of the symptoms of Depo, but I feel like I shouldn t be experiencing symptoms after 2 years. For maybe like the past 3 months, I ve spotting, on for about 3 weeks, off for 1, I was nauseous alot, & one day threw up everything I ate the entire day, but it wasnt food poisoning. Recently, I have been peeing ALOT, & it s not a UTI, I cramp sometimes & have headaches some days, & I ve never really gotten headaches before. My boyfriend & I do not use protection, & we are both STD free so could I be pregnant or just experiencing symptoms late? I have gained alot of weight, & have strecth marks but that could be Depo.