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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Suggest Ways To Manage Hypertension

hi; gThank you for answering my question, I am 61 years old female, I recently experienced high blood pressure and my doctor ordered the 24 hr urine test.vin I just got my result for metanephirine urine 24 hrs test , the result is 26, ( normal range 45-290 ug/24hr). it seems very low, what causes it, what would the symptom of having low metanephrine level? should I be concerned and take medications to bring it to normal level?
Wed, 25 Jul 2018
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Internal Medicine Specialist 's  Response
Hello and welcome to HealthcareMagic,

I read your question carefully and I understand your concern.
Please, do not worry. 24 hour urine metanephrines are tested to rule out adrenal tumor called pheochomacytoma. Pheochromocytoma is a catecholamine secreting tumor which presents with high blood pressure, headaches palpitations and sweating. Negative test results rule out phechromacytoma as the cause of hypertension. Low metanephrines in the urine indicates adrenal glands are producing lower levels of catecholamine hormones which might be normal feedback to hypertension. On the other hand some studies show low levels of metanephrines may indicate diabetes or pre-diabetic state.You should check blood glucose test to rule out diabetes as well.

I hope the above information will be helpful for you. Please, feel free to ask me if there is anything else you need to know.

Thank you,
Malik Amonov MD
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Suggest Ways To Manage Hypertension

Hello and welcome to HealthcareMagic, I read your question carefully and I understand your concern. Please, do not worry. 24 hour urine metanephrines are tested to rule out adrenal tumor called pheochomacytoma. Pheochromocytoma is a catecholamine secreting tumor which presents with high blood pressure, headaches palpitations and sweating. Negative test results rule out phechromacytoma as the cause of hypertension. Low metanephrines in the urine indicates adrenal glands are producing lower levels of catecholamine hormones which might be normal feedback to hypertension. On the other hand some studies show low levels of metanephrines may indicate diabetes or pre-diabetic state.You should check blood glucose test to rule out diabetes as well. I hope the above information will be helpful for you. Please, feel free to ask me if there is anything else you need to know. Thank you, Malik Amonov MD