Hello!! I received a series of ESIs for my spine 6 weeks ago. On that single date I was injected in two regions. L4,L5, and S1 for a herniated disc, as well as degenerative disc disease. My heart rate has been in the 100s and I have been irritable and anxious. I ve read that these symptoms indeed can occur with ESI injections. ESI injections are shown to stay in the system for approximately 2 weeks. I have felt these effects still at around 6 weeks. What are contributing factors as to why these injections durations would vary and be extended that long? I have also had two bladder infections in the period of a month. I know ESIs can impact your immune system. My OBGYN s office staff, as well as urgent care inquired about how much water I m drinking. Do ESIs have any other effects on any other body systems? I drink between 40 and 60 ounces of water a day. I weight 135. If there s anything that you know could be going on systemically if I m having a bad reaction, I would appreciate your insight. Thanks so much. - Julie