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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Are The Risks In Getting Married To Same Blood Genotype?

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Hello Doctor,

I want seek your professional advise with reagrds to my blood Genotype.

My name is Kayode am from Nigeria, the issue is that My wife to be and i share the same blood genotype- 'AS' this as been raising a lot of concerns from both family that we cannot marry cos there is chance of we giving birth to an ""SS"

pls kindly advice we really love each other
Thu, 8 Jan 2015
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General & Family Physician,  's  Response
If both you and your partner have an AS genotype then it comes down to probabilities. you have a 25% chance of having a child with a sickle cell anaemia. a 25% chance of a normal child and 50% chance of having AS children also called as a carrier state. Now there are ways that you can determine the genotype of a child while he/she are in utero but then religious / health restrictions may prevent you from carrying out an abortion if the child has a sickling trait. And probabilities are not cumulative I.e if say your first child has a sickling trait it does not mean the second will be normal. The second child again has 25% chance of having sickle cell anaemia. If you are in love I would urge you to consider adoption.
thank you for your query.
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Note: For detailed guidance on genetic screening consult a genetics specialist
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What Are The Risks In Getting Married To Same Blood Genotype?

If both you and your partner have an AS genotype then it comes down to probabilities. you have a 25% chance of having a child with a sickle cell anaemia. a 25% chance of a normal child and 50% chance of having AS children also called as a carrier state. Now there are ways that you can determine the genotype of a child while he/she are in utero but then religious / health restrictions may prevent you from carrying out an abortion if the child has a sickling trait. And probabilities are not cumulative I.e if say your first child has a sickling trait it does not mean the second will be normal. The second child again has 25% chance of having sickle cell anaemia. If you are in love I would urge you to consider adoption. thank you for your query.