Hello, Cannot say in your particular situation but I would say there is an important differentiation between withdrawal from medicine with new symptoms that are just with the withdrawal AND go away in days to week. OR resumption of the underlying condition that the medicine treated (which stays) or uncovering of other benefits the medicine did. So, with suboxone, people get less pain and 50% get a paradoxical increase in energy from the medicine. These benefits go away when the medicine isn t there. They will be exactly as tired and as achy as they would be without the medicine forever. Effexor is not generally associated with enlarged prostate nor blood pressure effects. Would these go away 3 to 5 days after the drug is stopped and the time the drug is not present? Doubtful. I cannot say in your particular case but some features to consider, if the prostate and hypertension stay whether or not there is a drug there, then those conditions are not so associated with the drug. If the withdrawal symptoms are exactly those that prompted someone to start a medicine, it is a reason to stay on the medicine. Hope I have answered your query. Let me know if I can assist you further. Take care Regards, Dr Matt Wachsman, Addiction Medicine Specialist