Hello Since you are an old diabetic patient ( NIDDM ) type 2 and your doctor advise you sitagliptine+metformine ( istamet ) and glimepride 4 mg . Sitagliptine never produces anorexia ( loss of appetite) while metformine some times causes loss of appetite . While glimepride also never causes any loss of appetite. Since you don t have any appetite but this is not a cause of concern. When such patient visit in my clinic i.e. diabetic patient . I advise my patient remain away from food maximum as you can do . Because a paerson at your age require only 1000 calories ,not more than this ,so don t worry about appetite , rather be happy that your blood sugar level is somewhat under control. But for appetite you can take a combination of cyproheptadine+ tricholin+sorbitol ( sugar free ) ,after consultation with your treating physician . Otherwise also this medicine will adjust within a short period. Please don t be irritate for appetite. Good luck.